If you were to gradually lose peripheral vision, you may may not notice for quite some time. Loss of central vision, however, will be quickly noticed. Loss of central vision is a result of damage to the macula. The progressive destruction of the macula is a disease known as macular degeneration and leads to the creation of a macular hole.
Malattia leventinese: An hereditary form of macular degeneration that results in progressive and irreversible visual loss. This disease is characterized by the appearance in early adulthood of small round white spots (drusen), particularly in the macula of the retina, which progress to form a honeycomb pattern.
For you bioscientist:
Malattia leventinese is inherited in an autosomal dominant manner. The disease is due to a single mutation (Arg345Trp) in FBLN_3, the gene encoding the protein fibulin 3. (This gene is also called EFEMP1.)
